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 Its the early nineteenth century, and young Dr. Noboru Yasumoto has been summoned for a reason unknown to him to rural Koishikawa Medical Clinic from Nagasaki, where he has been stationed for three years completing his internship. The clinic, headed by the outwardly stern Dr. Kyojô Niide - nicknamed "Red Beard" for that attribute - under his very strict guidelines, treats the poor and disadvantaged of the region. Much to his surprise and dismay, Yasumoto is told he is to start work there immediately, staff, including doctors, living on site. As he was expecting a position as a physician for a shogunate in his privilege, Yasumoto shows his displeasure at this fate at every turn. He believes this fate was either orchestrated directly by Red Beard in solely wanting access to his detailed professional notes - Yasumoto believing he a much better doctor than his new, more experienced superior - or by the father of a female acquaintance in an effort to get rid of him. Yasumoto may get a different perspective of life as a doctor at the clinic in getting to view Red Beards methods first hand, as he gets to know the stories of some of the in-patients at the clinic, and as he is assigned his first patient, Otoyo, a twelve year old orphaned girl who was raised in an abusive brothel environment in an effort to seal her supposed future.
In a charity hospital, a hard-bitten but honorable older doctor, Dr. Niide, takes a young intern under his guidance through the course of a number of difficult cases.
		 Toshirô Mifune 
 Dr. Kyojô Niide
		 Yûzô Kayama 
 Dr. Noboru Yasumoto
		 Tsutomu Yamazaki 
 Sahachi
		 Reiko Dan 
 Osugi
		 Miyuki Kuwano 
 Onaka
		 Kyôko Kagawa 
 Madwoman
		 Tatsuyoshi Ehara 
 Genzô Tsugawa
		 Terumi Niki 
 Otoyo
		 Akemi Negishi 
 Okuni, the mistress
		 Yoshitaka Zushi 
 Chôji
		 Yoshio Tsuchiya 
 Dr. Handayû Mori
		 Eijirô Tôno 
 Goheiji
		 Takashi Shimura 
 Tokubei Izumiya
		 Chishû Ryû 
 Mr. Yasumoto
		 Haruko Sugimura 
 Kin, the madam
		 Kinuyo Tanaka 
 Madame Yasumoto, Noboru's mother
		 Eijirô Yanagi 
 Madwoman's father
		 Kôji Mitsui 
 Heikichi
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