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 Dallas 1985. Electrician and sometimes rodeo bull rider Ron Woodroof lives hard, which includes heavy smoking, drinking, drug use (primarily cocaine) and casual sex. He is racist and homophobic. While in the hospital on a work related injury, the doctors discover and inform him that he is HIV+, and that he will most-likely die within thirty days. Ron is initially in angry denial that he would have a disease that only "faggots" have, but upon quick reflection comes to the realization that the diagnosis is probably true. He begins to read whatever research is available about the disease, which at this time seems to be most effectively treated by the drug AZT. AZT, however, is only in the clinical trials stage within the US. Incredulous that he, as a dying man, cannot pay for any drug which may save or at least prolong his life, he goes searching for it by whatever means possible. It eventually leads him to Mexico and a "Dr." Vass, an American physician whose license was revoked in the US because of his AIDS related work against US regulations. Dr. Vass leads Ron to a cocktail of other drugs, some vitamins, he believes are more effective in treating the symptoms, since the virus, as Ron learns, will always be in the system of those who have been exposed to it. Ron begins to smuggle these drugs not approved by the FDA into the US, not only for his own use but for sale to other HIV+ persons. In this venture, he goes into an unlikely partnership with a HIV+ transgender woman named Rayon, who he met in the hospital and who has greater contact with AIDS patients through the gay community. As they try to work both above ground to get the meds to those that need them and underground to avoid detection by especially the FDA, Ron comes up with an idea to circumvent the fact of selling the drugs - which are not considered drugs yet since they are not FDA approved - directly to the HIV+ population, which then should should not be against the law. Richard Barkley and Dr. Sevard, the FDAs lead man on the file and one of Rons doctors respectively, the latter who sees clinical trials as the only way to determine the efficacy of drugs despite the fact that Ron and others would have probably died already without these drugs, try to stop Ron and Rayon at every turn. Caught in the middle is Dr. Eve Saks, another of Rons doctors, who understands why policies are in place, but who can sympathize with Ron, Rayon and others - all her patients, directly or indirectly - in their situation.
In 1985, in Dallas, the homophobic electrician and rodeo rider Ron Woodroof is a cocaine user who frequently has sex with hookers and promiscuous women. When he has an accident at work, he is sent to the hospital where Dr. Sevard and Dr. Eve tell him that he is HIV+ and will die within thirty days. Ron also meets trans-gender Rayon, who is drug addicted and also has the disease. Ron does not accept the diagnosis but a couple of days later he realizes that it may be accurate. He researches about the disease and learns that AZT might be lethal for infected people. Further, he discovers that in Mexico there is a doctor with revoked license named Vass that uses alternative drugs in the treatment of AIDS. Ron improves his health and decides to sell the drugs in Dallas. He makes a partnership with Rayon and soon he creates the Dallas Buyers Club, where the memberships pay four hundred dollars per month to have the necessary drugs. But the FDA does not accept his research and he is oppressed by the authorities.
 
		 Matthew McConaughey 
 Ron Woodroof
 
		 Jennifer Garner 
 Eve
 
		 Jared Leto 
 Rayon
 
		 Steve Zahn 
 Tucker
 
		 Denis O'Hare 
 Dr. Sevard
 
		 Michael O'Neill 
 Richard Barkley
 
		 Dallas Roberts 
 David Wayne
 
		 Griffin Dunne 
 Dr. Vass
 
		 Kevin Rankin 
 T.J.
 
		 Donna Duplantier 
 Nurse Frazin
 
		 Deneen Tyler 
 Denise
 
		 JD Evermore 
 Clint
 
		 Ian Casselberry 
 Hispanic Orderly
 
		 Noelle Wilcox 
 Kelly
 
		 Bradford Cox 
 Sunny
 
		 Rick Espaillat 
 Michael
 
		 Lawrence Turner 
 Larry
 
		 Lucius Falick 
 Freddie
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