Doctor Strange teams up with a mysterious teenage girl from his dreams who can travel across multiverses, to battle multiple threats, including other-universe versions of himself, which threaten to wipe out millions across the multiverse. They seek help from Wanda the Scarlet Witch, Wong and others.
Following the events of Spider-Man No Way Home, Doctor Strange unwittingly casts a forbidden spell that accidentally opens up the multiverse. With help from Wong and Scarlet Witch, Strange confronts various versions of himself as well as teaming up with the young America Chavez while traveling through various realities and working to restore reality as he knows it. Along the way, Strange and his allies realize they must take on a powerful new adversary who seeks to take over the multiverse.
Bizarre visions of a mysterious teenage girl stranded in an unfamiliar dimension haunt Dr Stephen Strange shortly after the events of and . Indeed, a lot has changed since . But when Strange encounters the extraordinary girl from his dreams, the delicate boundaries between the current reality and an unfathomable alternate world start to collapse. Before long, horrific creatures working for nefarious forces wreak chaos, fusing parallel universes into a dangerous reality. Can Sorcerer Supreme Wong and invincible Wanda Maximoff help Strange stop the new adversary before the Multiverse of Madness consumes everything?