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 Convinced that his buddy Nardo (Thomas Middleditch) is making the mistake of a lifetime by marrying Tracy (Shannon Woodward), Jason (T.J. Miller) puts a dramatic end to their wedding. When the furious bride decides to take her Baja honeymoon solo, Nardo follows her-where the lovesick groom is carjacked and left stranded, naked and penniless in a remote part of the Mexican desert. Helpless, Nardo sends out an SOS to Jason and their pal Evan (Adam Pally), an up-and-coming ad exec slated for an important business meeting the next morning. During their ridiculous attempt to rescue Nardo, the trio embarks on a series of increasingly outrageous misadventures involving con artists, drug smugglers and even the Federales.
Roommates Evan, Jason and Nardo have been best friends since the third grade. They vow to be friends forever despite their lives moving in different directions. Nardo is finally about be married to his girlfriend Tracy. Evan is on the brink of a promotion to an executive position at work, it pending on an upcoming presentation. Evan has wanted to ask his senior associate Elizabeth out for over a year, but has resisted in not wanting to dip into the company well. And Jason is the big kid, which has led to a life of irresponsibility and bad judgment. Although Evan thinks it, Jason, from what Nardo says at the end of his bachelor party, acts upon his belief that Nardo doesnt really want to marry Tracy. Jasons action and Evans non-reaction leads not only to Jason and Tracy breaking up at the altar, but Nardo breaking ties with both his friends. While Tracy has gone on her and Nardos Mexican resort honeymoon on her own, Nardo has gone down to chase after and make it up to her in hopes of reconciling. In the process, Nardo gets stranded somewhere unknown in Mexico with literally nothing. As such, Jason drags Evan down to Mexico to rescue their friend wherever he may be. This trip threatens not only Adams promotion, but his job altogether and what may be more important to him his opportunity to get together with Elizabeth in a personal sense. In a broader perspective, both Adam and Jasons friendship is tested in their time together, and their lives and that of Nardo is put at risk as they each get into one misadventure after another.
 
		 Adam Pally 
 Evan
 
		 T.J. Miller 
 Jason
 
		 Thomas Middleditch 
 Nardo
 
		 Shannon Woodward 
 Tracy
 
		 Alison Brie 
 Elizabeth
 
		 J.B. Smoove 
 Berk
 
		 Octavio Gómez Berríos 
 Carlos
 
		 Maurice Compte 
 Pelon
 
		 Lance Reddick 
 MacDonaldson
 
		 Krysten Ritter 
 Christy
 
		 Rosa Salazar 
 Pocahontas
 
		 Jason Mantzoukas 
 Hugo
 
		 Jon Glaser 
 Marty
 
		 Steven Fernandez 
 Kenny
 
		 Liz Cackowski 
 Kenny's Mom
 
		 Laurie Singer 
 Hugo's Maiden
 
		 Codi Fischer 
 Bartender
 
		 Tracy Vilar 
 Sarah McLachlan
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