A doctor, wrongly convicted for a murder he didnt commit, escapes custody and must stay ahead of the police to find the real killer.
Dr. Richard Kimble is accused as the murderer of his wife, tried and convicted. On his way to be executed, he escapes. The only chance to prove his innocence is to find the man who killed his wife. Kimble, pursued by Lt. Gerard, risks his life several times when he shows his identity to help other people out of trouble.
Dr. Richard Kimble, a pediatrician in Stafford, Indiana, has an argument with his wife Helen and storms off. While returning his car almost hits a one armed man who darts out into the street from the vicinity of his home. Running into his home past the open front door, he sees Helen dead on the floor. Although innocent, he is tried and convicted for murder, and sentenced to death. Police Lieutenant Phillip Gerard is taking Kimble by train to prison to be executed, when the train derails and Kimble escapes. He travels from place to place, frequently changing his name, taking jobs where he can get them, usually menial, and ever on the alert lest he be recognized and captured. Lt. Gerard and other police are hot on his trail, and even well-meaning civilians can cause his ruin. While running, Kimble constantly seeks the one armed man so he can prove his innocence. Viewers can certainly believe in his innocence, since in each episode he displays outstandingly good character, frequently putting himself at risk to help another person in need. The fact he must frequently travel puts Kimble in a variety of interesting situations involving people of all different characters from all stations of life. Although he no longer has a medical license, his skills as a doctor are often needed and play a role in the drama. The main character, Richard Kimble, is intelligent, modest, generous, honest, hard-working, strong and trustworthy. Attractive to the ladies, he has many romances throughout his travels, and is always honest with them about the fact he never sticks around one town too long. Yet, the nature of being a fugitive occasionally requires some dishonest and even violent conduct on his part, though never too violent. His adversary, Lieutenant Phillip Gerard feels responsible for Kimbles escape, and Kimble is never far from his mind. Gerard is intelligent, honest, and completely devoted to duty. He does not bother himself with the question of whether Kimble is innocent, because the courts declared him guilty, and it is Gerards job to obey their orders. His shrewd detective skills often place Kimble in severe jeopardy. Kimble gets away at the end of every episode, sometime through his own efforts, sometimes through luck, and sometimes with the aid of a citizen, or even a policeman, who believes in Kimbles innocence or otherwise is impressed with his good deeds. The one armed man does not appear in many episodes, but is an evil presence throughout the series. When he does appear, he is ruthless, violent, and simple-minded, with good instincts for self-preservation. Like Kimble, he is a fugitive, having to run from the relentless pursuit of Kimble. Toward the end of the series he appears more often, and Kimble learns his name, Fred Johnson.