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Picking up immediately where Anaconda 3 left off, herpetologist Amanda Hayes finally learns her employer Murdochs true colors when he hires a doctor to harvest a fresh supply of blood orchids to experiment with the regenerative nectar on a baby snake in order to seek treatment for his own terminal illness. Amanda is forced to secretly bring together another team of scientists whom face off against a heavily armed squad of Murdochs men to steal the coveted orchids before the killer Anaconda hunts both parties down.
In a desperate attempt to cling to life, shortly after the terrifying events of , Murdoch enlists the help of a young doctor to harvest the rejuvenating serum of the rare Blood Orchids. Once more, a failed experiment leads to a new reptilian horror, as an ever-growing, genetically enhanced super-serpent breaks free from the laboratory. Now, the dauntless herpetologist, Amanda Hayes, and a handful of scientists must outsmart Murdochs armed-to-the-teeth henchmen, to have a fighting chance. But, can they put an end to the nightmare of the mutated Anacondas?
Crystal Allen
Amanda Hayes
Linden Ashby
Jackson
Danny Midwinter
Scott
Calin Stanciu
Alex
Ana Ularu
Heather
Claudiu Bleont
Armon
Anca Androne
Wendy
Emil Hostina
Eugene
Alexandru Potocean
Roland
John Rhys-Davies
Murdoch
Dan Badarau
Vasile
Marcel Cobzariu
Mercenary #1
Elias Ferkin
Mercenary #2
Razvan Gheorghiu
Mercenary #3
Vasile Albinet
Mercenary #4
Zoltan Butuc
Peter
David Frye
Armon
Cristina Teodorescu
Murdoch's Assistant
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