Under the tutelage of Rocky Balboa, newly crowned heavyweight champion Adonis Creed faces off against Viktor Drago, the son of Ivan Drago.
Years after Adonis Creed made a name for himself under Rocky Balboas mentorship, the young boxer becomes the Heavyweight Champion of the World. While life is good with that victory and his marriage to Bianca, trouble comes to Philadelphia when Ivan Drago, the Russian boxer who killed Adonis father, Apollo, arrives with his son, Viktor, to challenge Adonis. Against Rockys advice, Adonis accepts the challenge without his mentors participation and pays the price in a punishing bout he wins only by a technicality. Now injured and demoralized, Adonis cannot bring himself to back into the game, leaving his spirit and title in jeopardy. Together, Adonis family and Rocky must find a way to rekindle Adonis fighting spirit to face the future in whatever choice he makes. Meanwhile, the Drago family have its own troubles trying to regain the respect in their homeland that they lost at Rockys hands as they wonder whether is it truly worth it.
Three years after his loss to "Pretty" Ricky Conlan, Adonis Creed scores a string of victories, culminating in a victory over Danny "Stuntman" Wheeler (Andre Ward) to win the WBC World Heavyweight Championship. Now a worldwide star, Adonis proposes to his girlfriend, Bianca Taylor, who agrees to marry him. When Bianca suggests starting a new life together in Los Angeles, Adonis is reluctant to leave his life in Philadelphia behind. Meanwhile, Ivan Drago, a former Soviet boxer who killed Adonis father, Apollo Creed, in the ring thirty-three years earlier, sees an opportunity to regain the glory that was taken from him as a result of his loss to Rocky Balboa in Moscow later that same year by pitting his son, Viktor Drago (with the assistance of Buddy Marcelle, a promoter who has followed Viktors career closely), against Adonis. When Rocky refuses to support Adoniss decision to accept Viktors challenge, Adonis, feeling betrayed, decides to leave for Los Angeles.