A physician who can talk to animals embarks on an adventure to find a legendary island with a young apprentice and a crew of strange pets.
After his wifes death, Dr. John Dolittle (Robert Downey, Jr.) decided to hide from the world with his beloved animals. But he has to take a journey to a mysterious island to find a healing tree, which is the only medicine that can help the dying Queen Victoria (Jessie Buckley) in Buckingham Palace.
After his wifes death, the eccentric, famed doctor and veterinarian of Victorian England, John Dolittle (Robert Downey, Jr.) isolates himself away behind the high walls of Dolittle Manor with his animals for company. When Queen Victoria (Jessie Buckley) falls ill, a reluctant Dolittle is forced to go on an epic adventure to a mythical island in search of a cure, regaining his wit and courage as he crosses old adversaries and encounters wondrous creatures.