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Dr. Vasi (Rajnikanth) invents a super-powered robot, Chitti, in his own image. The scientific body, AIRD, that must approve the robot, declines it based on its not having emotions and the ability to make rational judgment. A sudden flash of lightning evokes emotions in the robot, and Chitti is seemingly ready for integration into the human world. Then, Chitti falls in love with Dr. Vasis fiancée Sana (Aishwarya Rai) and turns on his creator.
Chennai-based Dr. K. Vaseegaran spends day and night in constructing a human-android, and after many trials and errors does succeed in creating one in his own image. His girlfriend, Sana, decides to name him Chitti, and is very impressed by the way he not only rescues her from goons on a train, but also a woman from a fiery building; delivers a baby in the maternal ward of a hospital; and instructs mosquitos to keep away from her. Impressed by these turn of events, Vaseegaran decides to make Chitti more human by letting him feel emotions - this results in the latter not only rebelling but also getting obsessed with Sana and embarrassing the couple on the occasion of their formal engagement. Furious at these turn of events, Vaseegaran terminates Chitti and has it disposed off. But Dr. Bohra, who expects to net millions by such an android, reconstructs Chitti with a different chip - with results that will enable it to assist him to re-produce more such androids - as well as give the now malevolent, virtually indestructible and unstoppable Chitti the freedom to pursue Sana and re-populate Earth with a new species - Robo-Sapiens!!
Rajinikanth
Dr. Vaseegaran
Aishwarya Rai Bachchan
Sana
Danny Denzongpa
Dr. Bohra
Santhanam
Siva
Karunas
Ravi
Delhi Kumar
Vaseegaran's Father
Cochin Hanifa
Traffic Police
Kalabhavan Mani
Pachaimuthu
Devadarshini Chetan
Latha
Raaghav Ranganathan
Bad Boy Next Door
Sabu Cyril
Agent Shah
Revathi Sankaran
Dr. Vasigaran's Mother
Chaams
Barber
Sai Dheena
Thug
Sugunthan
Walkie-Talkie Inspector
Shriya Sharma
School student
Kriz Chris Henri Harriz
Austrian Goon
Shylaja Chetlur
Gynecologist
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