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Baron Frankenstein travels to a new town to meet Dr. Brandt with whom his has been corresponding and with whom he had hoped to collaborate. He arrives however to learn that Brandt is in a mental institution, having lost his mind completely. He takes a room in a boarding house run by the pretty young Anna who just happens to be engaged to Karl, a doctor who works at the asylum where Dr. Brandt is being kept. When Frankenstein learns that Karl has been stealing drugs, he blackmails him and Anna to work as his assistants. He is desperate to learn a secret that Brandt was going to share with him and kidnaps him with the intent of extracting that secret by transplanting his brain into another body.
Baron Frankenstein is once again working with illegal medical experiments - brain transplants to keep the most brilliant minds working in new bodies. He has just finished decapitating a physician for his work when a burglar, fleeing a patrolling officer, accidentally lets himself into the barons lab. The robber is horrified to see the head and flees to tell the police. Frankenstein knows this location is no longer viable and changes to a new city. He forces a young doctor, Karl, and his fiancee Anna to assist him after he catches Karl smuggling drugs from the mental institution where he works for Annas ailing mother. First, the baron wishes to rescue his fellow researcher, Dr. Brant, who is a patient at the mental institution. He is desperate to learn Brants secret about preserving brains. Brant is nabbed but is in bad physical shape having suffered a heart attack. He needs a new body immediately. So, the baron eliminates the asylum director, Professor Richter, whose body he can utilize. A nosy police inspector starts to put clues together about missing medical equipment and people who have vanished. His officers nearly stumble on Frankensteins lab but miss it. When Brant awakes by himself in his new body, he is not thrilled. Neither is his wife when he calls on her. She had already seen his original body in a hidden grave.
Peter Cushing
Baron Frankenstein
Veronica Carlson
Anna Spengler
Freddie Jones
Professor Richter
Simon Ward
Karl
Thorley Walters
Inspector Frisch
Maxine Audley
Ella Brandt
George Pravda
Doctor Brandt
Geoffrey Bayldon
Police Doctor
Colette O'Neil
Mad Woman
Frank Middlemass
Guest - Plumber
George Belbin
Guest - Playing chess
Norman Shelley
Guest - Smoking pipe
Michael Gover
Guest - Reading newspaper
Peter Copley
Principal
Jim Collier
Dr. Heidecke
Allan Surtees
Police Sergeant
Windsor Davies
Police Sergeant
Jack Armstrong
Reporter
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