Larry spans the globe, uniting favorite and new characters while embarking on an epic quest to save the magic before it is gone forever.
At the Museum of Natural History, theres a new exhibit being unveiled. Larry Daley, who manages the night exhibit where the exhibits come to life because of the Tablet of Ahkmenrah, is in charge of the presentation. But when the exhibits go awry, Larry finds himself in trouble. He learns the Tablet is corroding so he does some research and learns that Cecil, the former museum guard, was at the site when the Tablet was discovered. He tells Larry they were warned if they remove it could mean the end. Larry realizes it means the end of the magic. He talks to Ahkmenrah who says that he doesnt know anything. Only his father the Pharaoh knows the Tablets secrets. He learns that the Pharaoh was sent to the London museum. So he convinces Dr. McPhee, the museum curator, to help send him to London. He takes Ahkmenrah with him but some of the others tag along, like Teddy Roosevelt, Attila, Octavius, and Jedediah.
When Larry discovers that The Tablet Of Akhmenrah is corroding, thus causing his friends to act abnormally, he must travel to the British museum in order to find Akhmenrahs parents to help them reverse the corrosion before the magic disappears and the exhibits will go lifeless again.